Fasoracetam
A newer racetam that uniquely upregulates GABA-B receptors, making it potentially useful for people who have developed tolerance to GABAergic substances like Phenibut or benzodiazepines. It also enhances glutamate and acetylcholine signaling. Being studied in clinical trials for ADHD in adolescents with specific glutamate receptor gene mutations.
Dosage
Standard: 20-100 mg sublingually or orally, 1-3 times daily. Many users find 20-40 mg effective. Clinical trials for ADHD used 100-400 mg twice daily.
Dosages shown are for research reference only. Always consult a qualified healthcare provider.
Half-Life
1.5-2.5 hours
Administration
Oral or sublingual. Sublingual may provide better absorption.
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Mechanism of Action
Fasoracetam upregulates GABA-B receptor (GABA-B1/GABA-B2 heterodimer) expression and function, which is unique among racetams — this receptor upregulation is potentially beneficial for restoring GABAergic sensitivity after prolonged benzodiazepine or phenibut use. It enhances group II metabotropic glutamate receptor (mGluR2/mGluR3) signaling, which modulates presynaptic glutamate release and reduces excitotoxicity. Fasoracetam increases acetylcholine release in the cerebral cortex via modulation of choline acetyltransferase activity and vesicular acetylcholine transporter function. It may also modulate the glutamatergic system through mGluR5. The combination of GABAergic (GABA-B-mediated inhibition), glutamatergic (mGluR modulation), and cholinergic enhancement provides anxiolytic effects alongside cognitive enhancement. Clinical trials focus on ADHD patients with GRM (glutamate receptor) gene variants.
Regulatory Status
Investigational drug — in Phase 2/3 clinical trials for ADHD (Aevi Technologies/Neurofix). Available as a research compound.
Risks & Safety
Common
Headache, fatigue, mild digestive discomfort.
Serious
Limited long-term human safety data.
Rare
Low mood, brain fog, loss of motivation at very high doses.
Compare Fasoracetam With
Research Papers
5Published: January 15, 2018
AI Summary
NFC-1 treatment resulted in significant improvement. Parental Vanderbilt scores showed significant improvement for subjects with mGluR Tier 1 variants (P < 0.035).
Published: July 25, 2019
AI Summary
Given the high effect size found in RCTs of stimulants in terms of efficacy on ADHD core symptoms, it is unlikely that these novel agents will show better efficacy than stimulants, at the group level. However, they may offer comparable or better tolerability.
Published: May 18, 2017
AI Summary
Single-crystal X-ray analyses of the crystals show the existence of 2 hydrated and 1 non-hydrated crystalline form of fasoracetam. Under ambient conditions, the hydrate form I is found to be the most stable form, showing a melting point of 57C.
Published: March 8, 2024
AI Summary
Pharmacokinetic profiling revealed that Baptifoline, Odorinol, and Thyronine depicted an excellent therapeutic profile of druggability. These findings collectively substantiate the anticancer activity of bioactive metabolites synthesized by P. ramusculum SVWS3.
Frequently Asked Questions
What is Fasoracetam used for?
A newer racetam that uniquely upregulates GABA-B receptors, making it potentially useful for people who have developed tolerance to GABAergic substances like Phenibut or benzodiazepines. It also enhances glutamate and acetylcholine signaling. Being studied in clinical trials for ADHD in adolescents with specific glutamate receptor gene mutations.
What are the side effects of Fasoracetam?
Common: Headache, fatigue, mild digestive discomfort. Serious: Limited long-term human safety data. Rare: Low mood, brain fog, loss of motivation at very high doses.
How is Fasoracetam administered?
Fasoracetam is administered via oral or sublingual. sublingual may provide better absorption..
What is the half-life of Fasoracetam?
The half-life of Fasoracetam is 1.5-2.5 hours.
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