NALT
N-Acetyl L-Tyrosine is a more water-soluble form of the amino acid L-Tyrosine, which is a precursor to dopamine, norepinephrine, and epinephrine. It is used to support cognitive performance under stress, sleep deprivation, and high-demand situations where catecholamine stores become depleted. Military and high-performance research has validated tyrosine's benefits under acute stress.
Dosage
Standard: 300-600 mg NALT 1-2 times daily. Alternatively, plain L-Tyrosine at 500-2000 mg daily (better studied but less water-soluble). Best taken on an empty stomach 30 minutes before a stressful task.
Dosages shown are for research reference only. Always consult a qualified healthcare provider.
Half-Life
2-3 hours
Administration
Oral (capsules, powder). Take on an empty stomach for best absorption.
Shop NALT
99%+ purity · third-party lab tested
Mechanism of Action
NALT (N-acetyl L-tyrosine) is deacetylated by aryl acylamidase in the gut and liver to release L-Tyrosine. Tyrosine is hydroxylated to L-DOPA by tyrosine hydroxylase (TH) — the rate-limiting step in catecholamine synthesis, requiring tetrahydrobiopterin as cofactor. L-DOPA is decarboxylated by aromatic L-amino acid decarboxylase (AADC) to dopamine; dopamine is converted to norepinephrine by dopamine beta-hydroxylase (DBH), and norepinephrine to epinephrine by phenylethanolamine N-methyltransferase (PNMT). Under stress or sleep deprivation, catecholamine stores in noradrenergic and dopaminergic neurons deplete rapidly. Supplemental tyrosine provides substrate to maintain synthesis when demand exceeds supply, supporting prefrontal cortex function and working memory.
Regulatory Status
Dietary supplement worldwide. No prescription required. GRAS ingredient.
Risks & Safety
Common
Mild nausea on empty stomach, headache, heartburn.
Serious
May trigger hypertensive crisis in people taking MAOIs. Avoid with thyroid disorders without medical guidance.
Rare
Insomnia, anxiety, heart palpitations at high doses.
Compare NALT With
Research Papers
10Published: September 2, 2004
AI Summary
Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue (NALT) organogenesis is different from that of other lymphoid tissues. Moreover, intranasal immunization can lead to the induction of antigen-specific protective immunity in both the mucosal and systemic immune compartments.
Published: September 1, 2024
AI Summary
Within the upper and lower respiratory tract, the nasal and bronchial associated lymphoid tissues (NALT and BALT, respectively) are key sites where antigen-specific immune responses are orchestrated against inhaled antigens, serving as critical training grounds for adaptive immunity.
Published: December 17, 2017
AI Summary
Nasopharynx-associated lymphoid tissue (NALT) is one of the major constituents of the mucosa-associated lymphoid tissue (MALT), and has the ability to induce antigen-specific immune responses. Immunohistochemical analysis showed that CCL9 and CCL20 were co-localized with glycoprotein 2 (GP2) in the epithelium covering NALT, suggesting the existe...
Published: August 30, 2024
AI Summary
Here we define nasal glandular acinar structures and the turbinates as immunological niches that recruit IgA-secreting plasma cells from the nasal-associated lymphoid tissues (NALTs)3. CCL28 expression was increased in the turbinates in response to vaccination and promoted homing of IgA+ B cells to this site.
Published: September 1, 2015
AI Summary
Gal4-λN/BoxB reporter system revealed that the nuclear located NALT could function as a transcription activator which caused an activation of NOTCH signal pathway as confirmed by western blot. Taken together, we found a neighbor of NOTCH1, Lnc-RP11-611D20.2 (named NALT) which could regulate the NOTCH1 signal pathway through cis-regulation.
Published: April 14, 2025
AI Summary
Increased viral DNA and virus production were not detected in NALT explants when incubated with a medium lacking dexamethasone. Sorting cells from NALT of HSV-1 latently infected mice revealed that dendritic cells, microfold cells, and natural killer cells, but not B or T cells, harbor HSV-1 DNA, and infectious virus was readily detected when cu...
Published: August 25, 2015
AI Summary
There are still many open questions e. g., which adjuvant is necessary for a specific virus, bacterium or other allergen, how many doses are critical for an effective nasal vaccination. Species differences are of major importance when extrapolating results from rodents to humans.
Published: February 14, 2010
AI Summary
This nasal cavity-associated lymphoid tissue (NALT) has already been described in humans and many laboratory rodents, but data about rabbits are very scarce. Intraepithelial and lamina propria lymphocytes, and ILF's were, just like in humans, randomly distributed along the entire nasal mucosa.
Published: March 2, 2014
AI Summary
Intranasal (IN) immunization with a Plasmodium circumsporozoite (CS) protein conjugated to flagellin, a Toll-like receptor 5 agonist, was found to elicit antibody-mediated protective immunity in our previous murine studies.
Published: September 14, 2017
AI Summary
This complicates the understanding of the formulation influence on the immune response and the comparison of the different nanoparticles approaches developed. Moreover anatomical and immunological differences between rodents and humans provide an additional hurdle in the rational development of nasal nanovaccines.
Frequently Asked Questions
What is NALT used for?
N-Acetyl L-Tyrosine is a more water-soluble form of the amino acid L-Tyrosine, which is a precursor to dopamine, norepinephrine, and epinephrine. It is used to support cognitive performance under stress, sleep deprivation, and high-demand situations where catecholamine stores become depleted. Military and high-performance research has validated tyrosine's benefits under acute stress.
What are the side effects of NALT?
Common: Mild nausea on empty stomach, headache, heartburn. Serious: May trigger hypertensive crisis in people taking MAOIs. Avoid with thyroid disorders without medical guidance. Rare: Insomnia, anxiety, heart palpitations at high doses.
How is NALT administered?
NALT is administered via oral (capsules, powder). take on an empty stomach for best absorption..
What is the half-life of NALT?
The half-life of NALT is 2-3 hours.
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